Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health

May the joy and happiness around you today and always.
《琅琊榜》
脱发和头发变白的原因是相关的,科学家首次确认了对此负有责任的细胞。
尽管这笔节省下来的钱目前看来相当可观,但其实远不够填补随之而来的不断升高的患病率所增加的社会负担的窟窿。
俄罗斯把自己看作超级大国 -- 这在国内是毋庸置疑的。
法国兴业银行(Societe Generale)国际策略师基特?朱克斯(Kit Juckes)说,过去30年破灭的三个世界级金融大泡沫背后,都是“美联储(Fed)太久时间将政策利率维持在名义经济增长率之下”。
That comes in spite of official figures released on Tuesday showing China’s exports had contracted for a second straight month in October, suggesting domestic demand is the main driver of price gains for producers.
实际上,1至10月份的增速小幅升至8.3%。该指标大致反映了长期支出。
reg统治,ulate-管制
从该剧2007年首播至今,我们似乎患上了哈德利·弗里曼(Hadley Freeman)在《卫报》(The Guardian)上所称的“广告狂人狂热症”(madmenalaria)。
swimming;Synchronised swimming;diving;canoeing;Whitewater slalom;Still Water;Rowing;Sailing;Water Ball
1.Under no circumstances should you ask your taxi driver how excited he is about having the Olympics in London this summer. It's not that he will be reluctant or embarrassed to offer a personal opinion on the matter. That is not the problem at all.
It is revealed that Hadid's visa application was turned down after she offended many by squinting her eyes in an attempt to impersonate the Buddha in February.
Age: 44
而诺贝尔物理学奖则颁给了三位生于英国、目前正在美国工作的科学家,肯定了他们对极端状态下物质的特异属性所做的原子级研究。
5. Will China's migrant workers get permanent urban residence in 2010?
The first thing you must understand about personality types is that they have nothing to do with genes. This means that if you have a Type D personality then this doesn't mean that you can't change it. Also, the quiz doesn't mean that the result of the quiz determines your destiny. According to psychology, any personality trait can be changed.
2010年最让人痴迷的东西是备受期待的iPhone,其他受关注的对象还有女演员林赛 罗韩、iPad、电视节目《欢乐合唱团》和《泽西海岸》。
地区
The end of November is here. As I wrote Monday, recent history suggests nine teams have pretty much already been knocked out of playoff contention. Yet, none of them are straight-up tanking.
My arms are wide open for you this New Year.我张开双臂,盼与你共度新春佳节。
对于像费城、凤凰城和布鲁克林这样的烂队而言,另一个问题在于他们很难笼络到好的球队拼图。
当科比的身体长到了6尺6寸时,高中时期的他已经是一个相当中型身板的家伙。可以想象,在1996年,想抵挡住17岁的科比进攻就很难。我相信,这几乎是不可能的。
难怪各银行开始变得有创造力。
CEOs: Newbies Mary Barra at GM and Mark Fields at Ford start playing close attention to the moves made by FCA’s Sergio Marchionne. Despite running his growing empire on two continents, Marchionne tacked on a U.S market share gain of 1.2 points, unhindered by one of the weakest product lineups in the business and troubles with his much heralded eight-speed transmission.


On Nov. 24 and 25, Sotheby’s auctioned the collection of the fourth-generation Munich dealer Konrad Bernheimer, who owns the historic London gallery Colnaghi. Mr. Bernheimer, 65, has decided to scale down his operations. He is closing his Munich gallery, selling his grand Bavarian home, Marquartstein Castle, and is merging Colnaghi with a fellow London dealer, Coll & Cortes.
13) I am often down in the dumps 0 1 2 3 4
他说,到1997-98年亚洲金融危机爆发时,美联储的回应已变得更加迅速,它退出了紧缩周期,担心东南亚的动荡会影响美国经济。


With the increasing proliferation and sophistication of mobile phones, wearable devices such as smart watches, and sensors that can measure and gather a variety of data, public interest is growing in using consumer electronics to take ownership of personal health and wellness. A 2015 survey found that 66% of Americans age 66 and older want to use mobile technologies to improve their health by receiving medication reminders and tracking diet and nutrition, physical activity, and symptoms.[1

除了北方高等商学院和巴黎高等商学院以外,高等经济商业学院(Essec Business School)、巴黎高等商业学院-欧洲管理学院(ESCP Europe)和商科联盟国际商学院(Skema Business School)分列第三、第四和第六位。
在主要贸易伙伴中,以美元计的出口确实出现增长的包括对美国的出口,同比增长5.5%,达到370.6亿美元。而对韩国的出口也显示增长8.3%至102亿美元。
The reason is twofold: For one, logistically, there are simply too many opportunities to get caught job searching. Résumé copies will be found. Computer servers will be checked. Co-workers will notice when you're clearly elsewhere, either literally for interviews or emotionally (more on that later)。
这些人工眼睛,确实恢复了盲鼠的视力。猴子的视网膜工作原理和人类的非常相似,因此随后在猴子上进行的试验给了最终的人类试验以成功的希望。

Health apps and wearables
Health apps and wearables can unobtrusively gauge physiological and emotional states and collect, quantify, and monitor data regarding a user’s day-to-day behaviors. This “quantified self” can increase users’ self-awareness regarding their behavior and encourage positive changes to their overall health and well-being.[2] These commercially available devices also integrate an array of features to provide motivation through reward systems, opportunities for social in-teraction, tools for self-improvement, and prompts. The novelty, affordability, practicality, and ease of use have resulted in increased consumer enthusiasm and the pervasiveness of these devices.[3,4] With this growing interest in personal health, members of the general public are becoming more involved in monitoring and improving their own health habits.[5-10

Undoubtedly, merely tracking data through a device is not enough to maintain good health-related behaviors long-term, and the software must also incorporate motivational constructs important for the adoption and habituation of behaviors. For instance, a systematic review of studies that considered the use of electronic activity monitor systems found short-term changes in physical activity with self-monitoring, but no demonstration of superiority when the systems were compared with other interventions.[11] Another review of studies on the viability of using mobile technology for measuring and influencing physical activity found that most apps allow users to document their activity, set goals, review real-time feedback, connect to a social support network, and access online expertise.[12] However, less common among these apps were prompts to act and opportunities for problem solving and action planning, which are crucial constructs that translate intention into long-term behavior change.[13]

Sensor technologies
Sensor technologies have begun to enter the telehealth landscape and are primarily focused on continuous monitoring and precise diagnostics to inform management of various health conditions and diseases.[14-17] Sensors can be integrated into a watch or arm band or adhesive bandages and clothing, and then programmed to collect data on cardiac rhythm, heart rate, blood pressure, respiration, oxygen saturation, galvanic skin response, glucose levels, body temperature, body motions, ambient temperature, and global positioning. For health care providers, sensor inputs can permit remote monitoring, real-time teleconferencing, and timely care for patients with chronic diseases. For both patients and clinicians, telehealth supported by sensors can have profound implications. Clinicians can provide timely and patient-centred care to those living at a distance with chronic disease and can coordinate care when multiple providers are involved, reducing costs to the health care system.

A current clinical example is the management of paroxysmal atrial fibrillation with a mobile ECG and app that monitors the patient’s electrical rhythm to detect frequency and patterns of arrhythmias, and may even allow patients to share ultrasound and electrocardiogram data with their health care provider.[18-20] Telemonitoring with sensors can also support self-management of chronic diseases and detect early signs of deterioration in health requiring immediate treatment and advice.[21] Studies to date have demonstrated some clinical promise for the use of home telemonitoring in the context of heart failure and diabetes. A recent Cochrane review found that telemonitoring was an effective way to lower levels of glycated hemoglobin and low-density lipoprotein.[22] Although several studies on heart failure have produced conflicting results regarding the overall benefits of home monitoring,[23-26] systematic reviews have suggested that home telemonitoring reduces all-cause mortality and hospitalizations, and improves quality of life compared with usual care.[22,27] In addition, features such as automated and mobile telemonitoring appear to be more effective compared with other forms of home telemonitoring.[27]

Further studies are needed to determine how home health monitoring can improve patient safety during the transition from acute care to community care, and to examine the impact of home monitoring on health care costs. TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), an initiative of the University of British Columbia and Vancouver Coastal Health, is seeking to do this with prospective trials designed to uncover how telemonitoring can support the safety of heart failure patients discharged from hospital to home.[28]

Mobile apps, wearables, and sensors in the clinical setting
Even though mobile apps, wearables, and sensor technologies are promising, further research is needed to validate their use and long-term impact.[29] This research will require the collaboration of clinicians, health researchers, engineers, and computer scientists.[30] Understanding the possible risks of using these technologies, from physiological harm to breaching of privacy and confidentiality with insecure devices, and how to mitigate any risks is also important. Other important issues to consider include patient anxiety with overuse of technologies, health data piracy, self-diagnosis resulting from overreliance on self-monitoring, and patients not seeking help appropriately. These technologies should be used only as complementary tools in the treatment and prevention of health conditions and disease and should not be used in isolation by patients who self-diagnose and self-manage without consulting a health professional. 

“Domestic demand expanded at a sluggish pace while new export order growth eased to a five-month low ... We continue to expect further monetary and fiscal easing measures to offset downside risks to growth.”

Instant Heart Rate by Azumio.[31] A free app downloadable to both Apple and Android operating systems that measures heart rate and displays a monitoring strip. As well as helping users accurately track their heart rates, the app is capable of detecting irregular rhythms when palpitations occur. 

Sleep Time by Azumio.[32] A free app that monitors sleep patterns, sleep efficiency, and also acts as an alarm clock. Users can know how often they go into light and deep sleep, and recognize how much of these types of sleep will be necessary for them to feel rested, thereby quantifying the amount of true sleep they need and not just how long they should stay in bed. 

Bellybio Interactive Breating by RelaxLine.[33] A free app that helps users pace their breathing to achieve calmness. Placing the mobile phone against the abdomen, users can follow the sounds emitted to practise deep, abdominal breathing using this simple yet surprisingly effective tool. 

Concerns about China’s economy have recently dragged down global financial markets, affecting prospects for the eurozone and many others. Such worries are one reason why the European Central Bank is expected on Thursday to unleash a new round of economic stimulus.
Martin Ford, author of The Rise of the Robots , received the 30,000 Financial Times and McKinsey Business Book of the Year Award at a ceremony in New York on Tuesday.

mortality
University officials said the letter was now on its way to him along with a T-shirt from the university.
就业增长超出预期;
Retail sales of consumer goods, a key indicator of consumption, rose 10.7 percent year on year in China last year, contributing 66.4 percent to the country's GDP, the Ministry of Commerce said earlier this month.
源于:qualify(v 使具有资格;限制)
If the bounce is minimal and transitory it will be clear that the structural shift is under way. I hope the companies which are over invested in expensive projects and countries still overwhelmingly dependent on oil and gas revenues are ready.

Discernment to determine whether a particular app, wearable, or sensor can be effective.
Expertise and experience to guide patients on the use of technology.
Partnership with patients in pursuit of optimal health through technology use.
Trials to closely monitor benefits and drawbacks.
Humility to recognize that patients may know and invest much more time than physicians in looking for these tools.34

Conclusions
Based on today’s rapid pace of development and public enthusiasm for the technology marketplace, health apps, wearables, and sensors will soon become integral to our patients’ pursuits of good health and will need to be integrated in clinical practice. Physicians must be active agents in these evolutionary times, guiding patients, advocating for evidence to support the use of technologies, and participating in the development and incorporation of technology in patient wellness journeys. Through clinical stewardship and partnership with patients, physicians can use their expertise and experience to guide the growth of innovations into mainstream health care.

Competing interests
Dr Ho receives no personal financial compensation as the principal investigator of TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), a project funded by a Canadian Institutes of Health Research grant. This grant is matched by the Michael Smith Foundation for Health Research and the BC Ministry of Health, with additional support provided by TELUS Health and Sentrian. TELUS Health, Cisco, and Avizia have also provided equipment for display in Dr Ho’s Demonstration and Simulation Studio for Health (DaSSH) at UBC. Mr Yao and Dr Lauscher have no competing interests to declare.


北京南苑集体土地租赁房今天开工


References

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2. Swan M. Emerging patient-driven health care models: An examination of health social networks, consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009;6:492-525.

3. Gao Y, Li H, Luo Y. An empirical study of wearable technology acceptance in healthcare. Ind Manag Data Syst 2010;115:1704-1723.

4. Kim KJ, Shin DH. An acceptance model for smart watches: Implications for the adoption of future wearable technology. Internet Res 2015;25:527-541.

5. West JH, Hall PC, Hanson CL, et al. There’s an app for that: Content analysis of paid health and fitness apps. J Med Internet Res 2012;14:e72.

6. Abroms LC, Padmanabhan N, Thaweethai L, Phillips T. iPhone apps for smoking cessation: A content analysis. Am J Prev Med 2011;40:279-285.

7. Cowan LT, Van Wagenen SA, Brown BA, et al. Apps of steel: Are exercise apps providing consumers with realistic expectations? A content analysis of exercise apps for presence of behavior change theory. Health Educ Behav 2013;40:133-139.

8. Azar KM, Lesser LI, Laing BY, et al. Mobile applications for weight management. Am J Prev Med 2013;45:583-589.

9. Breland JY, Yeh VM, Yu J. Adherence to evidence-based guidelines among diabetes self-management apps. Transl Behav Med 2013;3:277-286.

10. Lyons EJ, Lewis ZH, Mayrsohn BG, Rowland JL. Behavior change techniques implemented in electronic lifestyle activity monitors: A systematic content analysis. J Med Internet Res 2014;16:e192.

11. Lewis ZH, Lyons EJ, Jarvis JM, Baillargeon J. Using an electronic activity monitor system as an intervention modality: A systematic review. BMC Public Health 2015;15:585.

12. Bort-Roig J, Gilson ND, Puig-Ribera A, et al. Measuring and influencing physical activity with smartphone technology: A systematic review. Sports Med 2014;44:671-686.

13. Rhodes RE, Yao CA. Models accounting for intention-behavior discordance in the physical activity domain: A user’s guide, content overview, and review of current evidence. Int J Behav Nutr Phys Act 2015;12:1-14.

14. Chen M, Gonzalez S, Vasilakos A, et al. Body area networks: A survey. Mob Networks Appl 2011;16:171-193.

15. Appelboom G, Camacho E, Abraham ME, et al. Smart wearable body sensors for patient self-assessment and monitoring. Arch Public Health 2014;72:28.

16. Chan M, Estève D, Fourniols JY, et al. Smart wearable systems: Current status and future challenges. Artif Intell Med 2012;56:137-156.

17. Alemdar H, Ersoy C. Wireless sensor networks for healthcare: A survey. Comput Networks 2010;54:2688-2710.

18. Haberman ZC, Jahn RT, Bose R, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J Cardiovasc Electrophysiol 2015;26:520-526.

19. Ferdman DJ, Liberman L, Silver ES. A smartphone application to diagnose the mechanism of pediatric supraventricular tachycardia. Pediatr Cardiol 2015;36:1452-1457.

20. Baquero GA, Banchs JE, Ahmed S, et al. Surface 12 lead electrocardiogram recordings using smart phone technology. J Electrocardiol 2015;48:1-7.

21. Wootton R. Twenty years of telemedicine in chronic disease management—An evidence synthesis. J Telemed Telecare 2012;18:211-220.

22. Flodgren G, Rachas A, Farmer A, et al. Interactive telemedicine: Effects on professional practice and health care outcomes. Cochrane Database System Rev 2015;(9):CD002098.

23. Mortara A, Pinna GD, Johnson P, et al. Home telemonitoring in heart failure patients: The HHH study (Home or Hospital in Heart Failure). Eur J Heart Fail 2009;11:312-318.

24. Dar O, Riley J, Chapman C, et al. A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: Results of the Home-HF study. Eur J Heart Fail 2009;11:319-325.

25. Chaudhry SI, Mattera JA, Curtis JP, et al. Telemonitoring in patients with heart failure. N Engl J Med 2010;363:2301-2309.

26. Koehler F, Winkler S, Schieber M, et al. Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: The Telemedical Interventional Monitoring in Heart Failure study. Circulation 2011;123:1873-1880.

27. Kitsiou S, Pare G, Jaana M. Effects of home telemonitoring interventions on patients with chronic heart failure: An overview of systematic reviews. J Med Internet Res 2015;17:e63.

28. TEC4Home Healthcare Innovation Community. Supporting heart failure patient transitions from acute to community care with home telemonitoring technology: A protocol for a provincial randomized controlled trial (TEC4Home). JMIR Res Protoc 2016;5:e198. 

29. Yao C, Ho K. Mobile sensors and wearable technologies. In: Amelung VE, Stein V, Goodwin N, et al., editors. Handbook integrated care. Cham, Switzerland: Springer; 2017.

30. Ho K, Borycki E, Kushniruk A, et al. The health perspective in using digital media for health and wellness. Presented at the IEEE International Digital Media Industry Forum, Boston, MA, 4-6 July 2016.

31. Azumio Inc. Instant heart rate. Accessed 28 August 2017. www.azumio.com/s/instantheartrate/index.html. 

32. Azumio Inc. Sleep time. Accessed 28 August 2017. www.azumio.com/s/sleeptime/index.html. 

33. RelaxLine. BellyBio. Accessed 28 August 2017. https://itunes.apple.com/ca/app/bellybio-interactive-breathing/id353763955?mt=8.

34. Ho K. How health information technologies are enhancing health of patients and their doctors. Presentation at the Alberta Medical Association 2015 Spring Representatives Forum, Edmonton, AB, 13 March 2015.


The growth has laid a solid foundation for the development of the film industry in China in the future, the experts added.
1. Love what you do.
“Australia stands out as a market that boomed when reform allowed it to switch from a commission-based model to a fee-based one,” says Mr Montanari. “This would be a game changer in Asia.”
In the wake of the Fitbit and Google’s GOOG 0.26% Glass, a flurry of companies has flooded the market with iterations of sensor-laden armbands, apparel, and eyewear. It’s a buzzy category, but early adopters seem to be waiting for a moment when they are no longerthat guy. (You know. The “Glasshole.”)
中国互联网金融行业继续保持快速增长的节奏。作为国内最大的个人对个人(P2P)网贷平台,陆金所(Lufax)正在寻求10亿美元的新融资,这将使其估值达到150亿至200亿美元。
俄罗斯总统普京说,无论谁在明年的美国总统大选中胜出,他都希望改善与美国的关系。
10.美国密歇根上半岛
1月,因本田未按要求向美国国家公路交通安全管理局汇报各类车辆上发生的1700多起伤亡事故,美国政府向该公司开具7000万美元的高额罚单。
The rise of ephemeral social networks
200911/90348.shtmlHere are the 10 winners of the 2012 Ig Nobel Prizes given to scientists, writers, and peacemakers who make silly but thoughtful contributions to the world, or as the Annals of Improbable Research puts it, "first make people laugh, and then make them think." I can vouch for them making us laugh!

Kendall Ho, MD, FRCPC, Christopher Yao, MSc, Helen Novak Lauscher, PhD. Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health. BCMJ, Vol. 59, No. 10, December, 2017, Page(s) 503-506 - Clinical Articles.



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Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

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另一种看法是,油价在过去三年中的变动,是长期结构性变化的开始,预示着下一个50年里,能源价格按实际值计算将显著低于上一个50年。简单地说,持这种看法的人认为,供给的增长潜力超过需求增长。
这会吓走一些人,这些人不了解你更好。
Song “Embrace Happiness”(Kelly Chen)
Will the AT&T/Time Warner merger go through without big remedies (such as the sale of CNN)

[k?ud]

  • Only the first three authors are listed, followed by "et al."
  • 4月中国红木进口综合价格指数发布
  • 武汉上月房价环比持平 本月楼市供应量井喷


对于新来的买家,这些变化能够给他们带来新的住房选择。但是对于既有居民而言,这可能意味着他们必须搬走。这点同样适用于De Robertis Pasticceria and Caffe等商铺。这家咖啡馆已经在东村(East Village)持续经营了110个年头,最近刚刚关门歇业。到明年,联合广场咖啡厅(Union Square Cafe)也可能会结束其在联合广场30年的运营。
The CSI 300, which consists of 300 of the top A-shares traded on the Shanghai and Shenzhen exchanges, is down 7 per cent and will be shut for the remainder of the day.

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