Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
In 2017, his 14th season in the league, LeBron James averaged a career high in assists and rebounds. In the first two months of 2017-18, he's averaging a career high in 3-point percentage, but that's been talked about and dissected; it's been written about extensively.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
在《醉乡民谣》(Inside Llewyn Davis)中，编剧兼导演乔尔?科恩(Joel Coen)和伊桑?科恩(Ethan Coen)兄弟俩挥之不去的忧伤情绪转化成了令人难忘的戏剧性场面。我觉得我的评论本应澄清，这部关于流行文化牺牲品的悲歌有一种特别的味道；其中一些部分相当阴郁。奥斯卡?伊萨克(Oscar Isaac)在片中出演一位自暴自弃的民谣乐手，宿命般地献身于他的艺术，他的卓越表演令这部影片极其震撼人心。
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
“We have resolved this matter and will move forward to build on the important actions Honda has already taken to address our past shortcomings in early warning reporting,” said RickSchostek, Honda executive vice president, in a statement. “We continue to fully cooperate with NHTSA to achieve greater transparency and to further enhance our reporting practices.”
Trends and targets in antiviral phototherapy
Perhaps my favorite profile this year was Kiki Zhao’s stirring depiction of the remarkable Yu Xiuhua, now one of China’s most read poets, a woman with cerebral palsy who lived most of her 41 years on a farm, writing at a low table. She never finished high school, and says she “could write before she could read.” Now, she is invited to places like Stanford University and fends off comparisons to Emily Dickinson.
Sales of previously owned homes have slipped every month since July, according to the National Association of Realtors. That coincides with the surge in borrowing costs across the economy as a result of the Fed's signals about its bond-buying program.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
"We are also witnessing a positive progress of diversification," he said. "In the past, most Chinese companies' patent filings were concentrated in the ICT sector, but now there are increasingly patents filed in engines, turbines, sports, automotive, and biotechnology sectors."
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The CPI rose by 2 percent.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
The Beijing Tourism Development Commission noted that the country's battle with pollution is another obstacle cities face in attracting inbound tourists.
Lots of managers recalled extreme etiquette errors. The applicant
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
China has continued to synchronize enterprises and institutions to raise the basic pension for over 100m retirees in 2017.
The term was first devised by psychologist Johan Denollet from Tilburg University who created a quiz to identify a type D personality.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
The studio says it has taken the step because the boy declined to remove a YouTube video he published which promoted how to use the software.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Having reached the current stage of development, China can now advance only through reform and innovation. We have the largest quality workforce as well as the largest pool of scientists, engineers and professionals in the world, and their potential for innovation is truly tremendous.
西门子(Siemens)去年破纪录了，通过将医疗部更名为Healthineers一举斩获两项大奖。该公司不仅因为将两个单词生拼硬造出另一个无比蹩脚的新词从而荣获“马丁?卢克斯奖”(Martin Lukes prize)，同时还凭借现场视频中一位倾情演唱的CEO和身着氨纶紧身衣卖力献舞的员工们，摘得史上最尴尬企业歌曲的金牌。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Have some respect for those who are promoting your work and hosting you to remove the gum before the interview begins.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Big and brassy! Paul McCartney (yes, yes, and also Wings) ushered in a new era of James Bond movies with the theme to Live and Let Die, sending the series careening into a 1970s musical sound as the franchise rebranded itself with a new leading man, Roger Moore. This is an almost maniacally excited song. The melody shifts and spirals and builds and sinks and hardly gives the listener a chance to get their bearings. It's a thrill.
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
Online banking and P2P lending has developed rapidly in China amid a push by Beijing to expand financing for consumers and small businesses. Upwards of 2,000 companies operate in China’s P2P lending milieu.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
In the wake of the Fitbit and Google’s GOOG 0.26% Glass, a flurry of companies has flooded the market with iterations of sensor-laden armbands, apparel, and eyewear. It’s a buzzy category, but early adopters seem to be waiting for a moment when they are no longerthat guy. (You know. The “Glasshole.”)
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The TV drama is not based on a novel but the story of a real businesswoman Zhou Ying. Born in the Qing Dynasty (1644-1911), Zhou was the richest female entrepreneur in Shaanxi province at that time.
Vawter climbed 103 floors of a Chicago skyscraper on his bionic leg, but its designers are still working on improving it. To optimize it for everyday use, they have to make it even thinner and lighter. Its successor (the iLeg Air?) may meet the Army's stated goal for a bionic leg—10,000 steps without recharging.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
We began the year worried that the US was poised to withdraw from the World Trade Organisation. That hasn’t happened. And it’s now unlikely to any time soon.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
The letter read: “The BFC shouldn't be endorsing a material whose production is deemed so cruel that it is outlawed in the UK.
Inhibition of SARS coronavirus helicase by bismuth complexes
Bingo! In fewer than 20 words it combined five previous years’ winners, only to say nothing at all. With a heavy heart, I award eBay my overall Golden Flannel Award for 2016.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
在2017年FT对全球95个管理学硕士项目的排行中，虽然瑞士圣加仑大学(University of St Gallen)继续蝉联冠军，但法国和英国商学院分别以24个和18个项目入围成为中坚力量。超过一半的英国商学院排名上升，而只有一家法国商学院排名上升。三分之一的英国商学院排名上升5位，相比之下，三分之二的法国商学院排名下降5位或更多。
SETTING: This house is in Kenwood, a neighborhood of 19th- and 20th-century Tudors, Mediterraneans, Victorians and colonial-style houses between Cedar Lake and Lake of the Isles, in the city’s Chain of Lakes. Roads are curving; sidewalks are lined with maple and ash trees. According to the listing agent, many of the neighborhood’s older houses have been restored, while houses built within the last 30 years have been torn down and replaced.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
这是伦敦商学院(London Business School)和哥伦比亚商学院(Columbia Business School)合办的EMBA-Global项目首次跌出前5名。
The office predicts the number of football schools will increase to 20,000 this year and reach 50,000 by 2025.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
这是今年最精致的浪漫电影与最尖锐的反浪漫电影，均来自美国电影界最缜密的聪明人。两部影片之间的关系最好用一首威廉·布莱克(William Blake)的诗歌来总结——《土块与卵石》(The Clod and the Pebble)。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
All told, Ujiri parted with Terrence Ross, Jared Sullinger, and a total of three picks to acquire the two veterans.
Stand: Costco CEO Craig Jelinek refused to open on Thanksgiving Day
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Why the difference? It wasn’t because of a difference in the available information. As Koudijs and Voth point out, everybody in Dutch financial circles knew and understood the magnitude of what had happened. Nor was it because the Seppenwolde lenders had to rebuild their own finances. Within weeks of the default, the lenders knew they hadn’t lost any money.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
“I don’t think there are any companies that have survived big assaults from two of the biggest beasts in the hedge fund jungle,” says Ms Simpson of Calpers. “He is cool, calm and collected — the corporate exemplar of ‘Keep calm and carry on’.”
伦敦商学院(London Business School，见上图)荣登2014年英国《金融时报》欧洲商学院排行榜榜首，该学院上一次夺得冠军宝座是在2005年。法国巴黎高等商学院(HEC Paris)和西班牙企业商学院(IE Business School)分列二、三位。
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
3. Grow your hair slightly longish, if it isn't naturally wavy (poor you), wear curlers to bed every night.
由于州政府和市政府试图打击不法的旅馆经营者，明年可能会出台一项规定。而与此同时，房产租赁网站Airbnb将游说政府改变法规。“你会看到，规范这一市场的要求会变得更加迫切。”代表租户的律师塞缪尔·J·希莫尔斯泰因(Samuel J. Himmelstein)说。
Ironically the list comes out the same day that Trump is meeting with Bill Gates, who is the world's richest man for the fourth straight year.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Among the top 10, four of them -- Pony Ma, Jack Ma, Ding Lei (CEO of Chinese game developer NetEase Inc) and Lei Jun (founder of smartphone maker Xiaoxi) -- are from TMT (telecommunications, media and technology) sectors.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
To Anita Eerland and Rolf Zwaan [THE NETHERLANDS] and Tulio Guadalupe [PERU, RUSSIA, and THE NETHERLANDS] for their study "Leaning to the Left Makes the Eiffel Tower Seem Smaller."
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Most Catholics (60 percent) and white non-evangelical Protestants (65 percent) say they believe disasters like hurricanes and floods are the result of climate change.
Amy Poehler made out with Bono, Tina Fey mocked George Clooney's taste in women and Matt Damon emerged, bizarrely, as the night's recurring gag.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Interestingly, a survey found Beijing was thought to be the most congested city in China, among 31.8 percent of respondents, followed by Zhengzhou at 8.8 percent.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The overall 2018 ranking encompasses more schools than ever before – 1,250 universities located across 74 countries. This is an increase from the 1,000 schools in 65 countries included in last year's edition.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Klay Thompson added 19 points and Andrew Bogut scored 13 for the Warriors, off to the best start by an NBA team since Dallas won its first 14 games in 2002-03. Golden State needs three wins to equal the league record of 15-0, held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.
This umbrella protects your dogs from the sun and rain.
Finding Dory releases on June 17, 2016.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Mr Baweja’s extensive analysis on the changing nature of globalisation suggests the prime factor behind the weakness of global trade growth (which for a long time expanded at twice the rate of global GDP) has been a slowdown in investment.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
I wonder if the Pelicans are in that position, too. It looks like their highest Brow-era pick will be Buddy Hield. That's not optimal.
Until four years ago, Maddie was an unknown eight year old who enjoyed dancing and went to a local primary school.
China is committed to denuclearization of the Korean Peninsula, the peace and stability in the Korean Peninsula, and resolving issues through dialogue and consultation. That is China’s consistent and clear-cut position.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Will emerging market GDP growth pass 5 per cent
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The Dutch case involved sophisticated financial professionals, people accustomed to analyzing financial and economic trends. Yet, they too focused on their personal experience.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
James Bond 23 may still be quite a ways away from actually happening, as star Daniel Craig is commited to three chapters in the Millennium Trilogy, starting with the currently in-production The Girl with the Dragon Tattoo. There is currently no talk of hiring someone else to play James Bond, but if Craig is to reprise the role a third time, we still won't see James Bond 23 until 2014 at the earliest.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
All held together with imported white stilton cheese, the flakes are interspersed on the pie with dollops of Ossetra caviar from the Caspian Sea as well as truffles and Fois Gras from France.
More advanced components are in short supply, however, which could leave many customers waiting long after September to get hold of the new iPhone. That presents an opportunity for rivals such as Samsung’s new Note 8 or Essential, the smartphone maker led by Android co-founder Andy Rubin, which is targeting premium customers such as Apple’s with its slick $699 device. Google is also said to be preparing a new version of its Pixel smartphone, which has proved popular with early adopters.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
There are, of course, complicated contours to 2016’s unusual politics. In Britain, immigrants from South Asia voted heavily to leave the European Union, citing hopes that curtailing European migration might open space for more people from Asia. In the United States, frustration with and alienation from status quo politics have helped drive Mr. Trump’s rise.
与此同时，前第五届和声明星 Camila Cabello证明了她的独唱生涯正在起飞，因为她的首张单曲《Havana》获得了最佳流行音乐奖。她的胜利意味着Taylor Swift失去了另一个奖项，尽管这对于歌手来说只是众多收获中的一个，但是近期她因为一年的沉寂过后又重新成为焦点。
Will the Democrats take back the majority in the midterm election in the US House of Representatives
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
It's a travel pillow that bends to support your head in any position.
Baby Driver is so much fun, although it's not necessarily non-stop LOLs, it's definitely non-stop lowercase lols.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Certainly, the emails have already started flooding in celebrating various products in shades of Rose Quartz and Serenity. But I wonder: Are we suddenly going to see a host of blended pastel ties, as opposed to the currently popular red and blue, popping up in the next round of presidential debates? Place your bets now.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
The number of university graduates reached 7.65 million in 2016, hitting a new historic high, the Beijing News reported. Plus, the number of students graduating from secondary vocational schools hit 4.35 million, bringing the total figure to 12 million.
If nothing else, it's clear that when it comes to the summer, the NBA season doesn't really ever stop. It just switches gears.
Length-scale dependence of protein hydration-shell density
The Harry Potter star Emma Watson hold fifth position in the list of ten most beautiful women of 2015. The English actress, model, and activist, Watson took the top spot on the AskMen “Top 99 Outstanding Women 2015″ list and at number 26 on the TIME 100 list of the world's most influential people.
HOUSE OF CARDS (Netflix, Feb. 27) Netflix’s political grand guignol gets a 13-episode third season. Kim Dickens of “Treme” joins Kevin Spacey and Robin Wright in the cast, and two members of Pussy Riot will make a guest appearance.
'That's something that would be challenged, I think, in the 21st century.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A median forecast from economists had predicted a 0.9 per cent rise.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
7) Let Me Play Devil’s Advocate: Looking for a subtle way to critique? Turn the conversation into an exercise where you’re a detached party performing a function: Poking holes in the logic and plan of attack. You use this strategy to stress test ideas without making the process personal.
A new MIT white paper, ominously entitled "Are You Prepared for the Supply Chain Talent Crisis?," bears that out. Supply chain managers need sophisticated tech skills, sure, but they also have to be adept at "high-order diplomacy," expert at general business strategy and problem solving, and able to "thrive in ambiguity," the study says.
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We will deepen institutional reform to build a sound ecological environment.